Fundus autofluorescence is a noninvasive imaging technique used to detect naturally occurring fluorescence within the eye or fluorescence produced as a result of disease processes, often before changes become visible through other imaging methods. FAF is particularly useful for evaluating the health and distribution of retinal pigment epithelial (RPE) cells and lipofuscin, a byproduct of cellular metabolism that can accumulate in various retinal disorders. This technology allows us to map areas of retinal stress or damage and is especially valuable in diagnosing and monitoring conditions such as age-related macular degeneration, retinal dystrophies, and central serous chorioretinopathy. FAF provides unique insights that complement findings from other imaging modalities, such as OCT or fluorescein angiography, enabling a more comprehensive assessment of retinal health.